Rapamycin formulation for iv injection

Abstract From the Canadian patent

Disclosed herein is an aqueous injectable rapamycin solution, obtainable by a process comprising mixing 5 to 30 volume percent of a concentrate solution of rapamycin in propylene glycol, at concentrations of rapamycin ranging from 0.5 mg/ml to 10 mg/ml, with a diluent solution comprising 0.1 to 10 weight percent of one or more polyoxyethylene sorbitan esters, 10 to 60 weight percent of polyethylene glycol 200, 300 or 400 or a combination thereof and 30 to 89.9 volume percent water wherein the concentration of rapamycin in the injectable solution ranges from 0.025 mg/ml to 3 mg/ml. Also disclosed is a pharmaceutical product containing such concentrate solutions of rapamycin and such diluent …