Quinuclidine derivatives as substance p antagonists

Abstract From the Canadian patent

Compounds useful in the treatment of inflammatory disorders central nervous system disorders and other disorders of formula (I) and the pharmaceutically-acceptable salts thereof wherein X1 is alkoxy or halosubstituted alkoxy; X2 is hydrogen halogen, alkyl, alkenyl, alkynyl, alkoxy alkylthio, alkylsulfinyl, alkylsulfonyl halosubstituted alkyl, halosubstituted alkoxy alkylamino, dialkylamino, alkylsulfonylamino (which may be substituted) N-alkyl-N-alkylsulfonylamino (which may be substituted), alkanoylamino (which may be substituted) or N-alkyl-N-alkanoylamino (which may be substituted); Ar1 and Ar2 are each, independently, thienyl, phenyl fluorophenyl, chlorophenyl or bromophenyl; A is …