Substituted pipecolinic acid derivatives as hiv protease inhibitors

Abstract From the Canadian patent

Disclosed herein are compounds of formula (I) wherein X is a terminal group for exemple, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an amino acid residue,for example Val or Asn; R1 is hy-, drogen or a ring substituent for example, fluoro or methyl; R2 is alkyl; and Y is a ring substituent for example, phenoxy, 2-pyridinylmethoxy phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.