Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
CA 2129144 C · Owner: Sunkara, Sai Prasad · Inventors: Sunkara, Sai Prasad; Palopoli, Frank P.; Freedman, Jules
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A compound of formula (I) wherein Ph1, Ph2 and Ph3 are each a phenyl group optionally substituted with a combination of up to three members of the group consisting of fluoro chloro, bromo, hydroxy, trifluoromethyl NH2, N(CH3)2, (C1-4) alkyl and (C1-4)alkoxy or the phenyl group can be substituted with a methylenedioxy group; n is an integer of from 1 to 5; m is 0 or an integer of from 1 to 2; and q is an integer of from 1 to 2; or an acid addition salt thereof which reverse, multidrug resistance in multidrug resistant tumor cells and are thus useful adjuvants in the treatment of tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed January 11, 1993 and granted July 13, 1999. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended January 11, 2013.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by January 11, 2015.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.