Immunogenic detoxified mutants of cholera toxin and of the toxin lt, their preparation and their use for the preparation of vaccines
CA 2127091 C · Owner: Pizza, Mariagrazia · Inventors: Pizza, Mariagrazia; Domenighini, Mario; Rappuoli, Rino
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
An immunogenic detoxified protein, comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-104 or Pro-106 are replaced with another amino acid or deleted. Examples of specific replacements include Val-53-Asp; Val-53-Glu, Val-53-Tyr, Ser-63-Lys; Val-97-Lys, Val-97-Tyr, Tyr-104-Lys, Tyr-104-Asp Tyr-104-Ser, Pro-106-Ser. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 30, 1992 and granted August 1, 2000. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 30, 2012.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 30, 2014.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.