Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof

Abstract From the Canadian patent

Preparing acetals and hemi-acetals of formulas (VII) or (V), and , wherein Ar represents aryl or substituted aryl; R represents alkyl, substituted alkyl, cycloalkyl cycloalkylalkyl, hydroxyalkyl, aryl, substituted aryl arylalkyl, substituted arylalkyl, heterocyclic or heterocyclic alkyl and R3 represents hydrogen alkyl, aryl or substituted aryl, comprising contacting a compound of formula (II):, wherein Ar and R3 are as defined above and L is a leaving group, with a sulfoxide and an alcohol of the formula ROH wherein R is as defined above or, alternatively, contacting a compound of formula (I): wherein Ar and R3 are as defined above with a, halogenating agent, a sulfoxide and an alcohol of, …