Use of bisphosphonic acid derivatives for promoting bone repair and corresponding drugs

Abstract From the Canadian patent

The present invention relates to the use of bisphosphonic acid derivative of formula (I):, (see fig. I) in which:, - R1 is a hydrogen atom, a halogen atom a hydroxyl, an amino, a mono-C1-4-alkylamino or a di-C1-C4-alkylamino, and, - R2 is a halogen atom or a linear alkyl containing from 1 to 5 carbon atoms which is unsubstituted or substituted by a group selected from a chlorine atom a, hydroxyl, an amino, a mono-C1-C4-alkylamino a di-C1-C4-alkylamino and a, C3-C7-cycloalkylamino or R2 is a phenoxy, a phenyl, a thiol, a phenylthio a, chlorophenylthio, a pyridyl, a pyridylmethyl a 1- pyridyl-1-hydroxymethyl, an, imidazolylmethyl or a thiomorpholin-4-yl; and their salts with pharmaceutically …