Substituted nitrogen containing spiro compounds for use in treating cognitive deficits

Abstract From the Canadian patent

There are provided novel spirocyclic compounds of formula (I) or, physiologically suitable salts thereof wherein: X and Y are, taken together to form a saturated or unsaturated carbocylic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aromatic ring or heteroaromatic ring fused to the first ring; Z is O, S, N-NH2 2 hydrogen atoms, or H , and OH; one of Het1 or Het2 is 2- 3-, or 4-pyridyl, or 2-, 4-, or 5-pyrimidinyl and the other is selected from the group including: 2-, 3-, or 4-pyridyl, 2-, 4or 5-pyrimidinyl, 2-pyrazinyl, 3- or 4-pyridazinyl 3- or 4-pyrazolyl, 2- or, 3-tetrahydrofuranyl and 3-thienyl; pharmaceutical compositions …