Indole derivatives as steroid 5 alpha-reductase inhibitors

Abstract From the Canadian patent

The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein X is, O, NH, N(C1-C4 alkyl), direct link C1-C4 alkylene, C2-C4 alkenylene or C2-C4 alkynylene said alkylene, alkenylene and, alkynylene being optionally substituted by C1-C4 alkyl or aryl; Y is methylene C2-C6 alkylene optionally interrupted by O C2-C6 alkenylene or C2-C6 alkynylene, all of which may be optionally substituted by C1-C6 alkyl or is a group of formula, (II) wherein m and n are each independently selected from O and an integer of from 1 to 5 with the proviso that the sum of, m and n is not greater than 5 and p is an integer of from 2 to 6; R is H OH, halo, C1-C4 …