The use of nucleic acid analogues in diagnostics and analytical procedures

Abstract From the Canadian patent

Methods of capture, recognition detection, identification or quantitation of nucleic acids and diagnostics uses generally are described in which are used (a) a peptide nucleic acid (PNA) comprising a polyamide backbone bearing a plurality of ligands at respective spaced locations along said backbone, said ligands being each independently naturally occurring nucleobases non-naturally, occurring nucleobases or nucleobase-binding groups each said, ligand being bound directly or indirectly to a nitrogen atom in said backbone, and said ligand bearing nitrogen atoms mainly being separated from one another in said backbone by from 4 to 8 intervening atoms;, (b) a nucleic acid analogue capable of …