Methods and compositions for the selective inhibition of gene expression
CA 2108144 A1 · Owner: Roth, Jack A. · Inventors: Tainsky, Michael; Roth, Jack A.; Mukhopadhyay, Tapas
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Disclosed are methods and compositions for the selective inhibition gene expression through the application of antisense RNA technology. Antisense RNA constructs of the present invention employ the use of antisense intron DNA corresponding to distinct intron regions of the gene whose expression is targeted for down-regulation. In an exemplary embodiment a human lung cancer cell line, (NCI-H460a) with a homozygous spontaneous K-ras mutation was transfected with a recombinant plasmid that synthesizes a genomic segment of K-ras in antisense orientation. Translation of the mutated K-ras mRNA was specifically inhibited whereas, expression of H-ras and N-ras was unchanged. A three-fold growth …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 6, 1992. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 6, 2012.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 6, 2014.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.