Morphinan derivative and its pharmaceutical applications

Abstract From the Canadian patent

There is disclosed morphinan derivative represented by the general formula (I) or its pharmacologically acceptable acid addition salt:, (see fig. I), ~ represents a single or double bond. R1 represents an alkyl group having 1-5 carbon atoms, a cycloalkylalkyl group having 4-7 carbon atoms, a cycloalkenylalkyl group having 5-7 carbon atoms, an aryl group having 6-12 carbon atoms an, aralkyl group having 7-13 carbon atoms an alkenyl group having, 4-7 carbon atoms an allyl group, a furan-2-ylalkyl group having 1-5 carbon atoms, or a thiophen-2-ylalkyl group having 1-5 carbon atoms. R2 represents a hydrogen atom a hydroxy, group, a nitro group, an alkanoyloxy group having 1-5 carbon atoms, an …