1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders

Abstract From the Canadian patent

A class of 1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are angiotensin II antagonists of the formula (I) wherein A is selected from (1, 2, 3, 4, 5 and 6), wherein m is one; wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl n-butyl, sec-, butyl, isobutyl, tert-butyl 4-methylbutyl, n-pentyl, neopentyl, phenyl benzyl, phenethyl, 2-ethylbutyl, 1,1-difluorobutyl N-, methylamido, N-methyl-N-tertbutylamido 2-methylphenyl, 2-isopropylphenyl, 2-, methoxyphenyl 2-chlorophenyl, 2,6-diflu-, orophenyl, cyclohexyl cyclohexylmethyl, 2-butenyl, 3-butenyl …