Protein production from immortal cells grown in vivo
CA 2104787 A1 · Owner: White, David J. G. · Inventors: Van Den Bogaerde, Johan B.; White, David J. G.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Antibodies or other protein derived from a given species can be produced in a discordantly related host animal of choice by culturing a hybridoma or other immortal protein-producing cell line in the peritoneal cavity of the host animal if both the humoral, immune response and the cell-mediated immune response of the host animal are compromised. The humoral immune response can be compromised congenitally; so for example C3-deficient animals can be used. The cell-mediated immune response is preferably compromised by administering cyclosporin A. This enables human-derived antibodies to be produced in vivo and in general it allows the scaling up of in vivo production methods by using larger …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 16, 1992. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 16, 2012.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 16, 2014.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.