Methods for selection of recombinant host cells expressing high levels of a desired protein
CA 2104598 C · Owner: Cohen, Justus B. · Inventors: Cohen, Justus B.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to improved methods for the selection of recombinant host cells expressing high levels of a desired protein, which methods are useful with a wide variety of eukaryotic host cells and avoid the problems inherent in existing cell selection technology. The invention further relates to intron-modified selectable genes, comprising the coding sequence of a selectable gene and an intron that reduces the level of selectable protein produced from the selectable gene in a host cell which, are useful in the methods of the invention.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed February 20, 1992 and granted January 7, 2003. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended February 20, 2012.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by February 20, 2014.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.