Process for the c-terminal modification of peptides having a c-terminal penultimate proline residue
CA 2101074 A1 · Owner: Aasmul-Olsen, Stig · Inventors: Christensen, Kurt A.; Widmer, Fred; Aasmul-Olsen, Stig
Overview
Its claims, description and drawings are in the Canadian Patents Database.
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2101074 9215695 PCTABS00016, C-terminally modified peptides of the formula Peptide - Pro - NH-R, wherein R is selected from hydrogen hydroxy, C1-6 alkyl, hydroxy C1-6 alkyl and C6-9 aralkyl or R is NHR1 wherein R1 is hydrogen C1-6 alkyl, C6-9 aralkyl or a group CO-R2 wherein R2 is selected from NH2, C1-6 alkyl and C6-9 aralkyl, e.g. calcitonin, are prepared by reacting a substrate component of the formula Peptide - Pro - X wherein X is an amino acid, having a side chain comprising at least two carbon atoms and further comprising at least one hetero atom selected from N O and S, with a nucleophile component NH2-R wherein R has the above, meaning in the presence of an L-specific serine or …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 2, 1992. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 2, 2012.
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