Amidic derivatives of glutamic, aspartic and 2-amino adipic acids with antigastrin activity

Abstract From the Canadian patent

Bicyclic and polycyclic amidic derivatives of glumatic aspartic , and 2-amino adipic acids having activities antagonistic to gastrin, of general formula (I) in which r is between 1 and 3 and R1 is selected from mono- and disubstituted phenyl groups and in, which the substituents are selected from chlorine linear and, branched C1-C4 alkyl groups cyano, nitro, methoxy, and, trifluoromethyl groups and the 2(beta)-naphthyl group, and heterocyclic monocyclic or bicyclic groups containing one heteroatom such as nitrogen, oxygen or sulphur and selected from furyl thiophenyl, pirrolyl, pyridinyl, and pyridinyl-N-oxide unsubstituted or mono- or disubstituted with methyl and chlorine indolyl, …