Method for preparing 7-oxabicycloheptyl substituted oxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds
CA 2096667 A1 · Owner: Singh, Janak · Inventors: Mueller, Richard H.; Singh, Janak
Overview
Its claims, description and drawings are in the Canadian Patents Database.
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HA620a, Abstract, METHOD FOR PREPARING 7-OXABICYCLOHEPTYL SUBSTITUTED OXAZOLE AMIDE PROSTAGLANDIN ANALOG INTERMEDIATES USEFUL IN THE PREPARATION OF ANTI-THROMBOTIC AND ANTI-VASOSPASTIC COMPOUNDS, A method is provided for preparing oxazole intermediates of the structure, (wherein R is alkyl) wherein an oxazoline of the structure, is oxidized employing an oxidizing agent such as cupric bromide, a base such as 1,8-diazabicyclo- 5.4.0undec-7-ene (DBU), and a non-hydride donor amine base such as hexamethylenetetraamine (HMTA). The resulting oxazole may be hydrolyzed to the final anti-thrombotic - anti-vasospastic compounds.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 20, 1993. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended May 20, 2013.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 20, 2015.
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