Semi-synthetic glycosaminoglycans containing .alpha.-l-galacturonic acid substituted with nucleophilic radicals in position 3

Abstract From the Canadian patent

The synthesis of new semi-synthetic glycosaminoglycans is described in which one of the saccharide units characteristic of glycosaminoglycans with heparin or heparan structure, more specifically that of .alpha.-L-iduronic-2-O-sulfate acid, has undergone a structural modification entirely or in, part, with transformation into .alpha.-L-galacturonic acid substituted with nucleophilic radicals in position 3. These new semi-synthetic glycosaminoglycans of general formula IV (see fig. I), have good pharmaceutical properties in that they may also be absorbed orally and have good anti-thrombotic activity accompanied by low risk of hemorrhage and reduced anti-coagutating activity.