Preparation and characterization of liposomal formulations of tumor necrosis factor
CA 2091771 A1 · Owner: Klostergaard, Jim · Inventors: Utsumi, Toshihiko; Klostergaard, Jim; Hung, Mien-Chie
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A novel TNF-preparation with high cytolytic activity is disclosed. The TNF preparation includes modified forms of tumor necrosis factor associated with the surface of liposomes of small diameter (between 0.02-0.05 µm) known as SUV's. The tumor necrosis factor molecule is modified at up to 3 amino residues per trimer with nearly complete retention ($m(k)80-95 %) of biological activity. The modified TNF amino residues are modified to include long chain fatty acids via TNF lysyl side chains and/or N-terminal amino groups. The disclosed modified TNF molecules provide a highly efficient method for preparing liposome-associated TNF complexes in either standard MLVs or SUVs having enhanced in …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 16, 1991. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 16, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 16, 2013.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.