Protein polyligands joined to a stable protein core

Abstract From the Canadian patent

Stable polyligands are provided by preparing fused proteins where the fused protein comprises a ligand at one terminus and a subunit or a multimeric unit protein at the other terminus where the, fused protein is able to assemble to provide a polyligand. The polyligands find use in modulating physiological processes by inhibiting ligand induced signal transduction by surface membrane protein receptors and/or in the case of µ chain use by, complement mediated killing or any other effector functions. The molecule may be composed solely, of human components to avoid an immune response by the recipient.