Preparation of acylaminomethanephosphonic acids and acylaminomethanephosphinic acids

Abstract From the Canadian patent

Acylaminomethanephosphinic acids, and a process for the preparation of acylaminomethanephosphonic acids and acylaminomethylphosphinic acids, Acylaminomethanephosphonic acid and acylaminomethylphosphinic acids of the formula I, R2 - CO - NH - CH2 - P(O)(OH)R1 (I) in which R1 is hydroxyl, C1-C4-alkyl or phenyl and R2 is H C1-C5-alkyl, benzyl or phenyl, unsubstituted or substituted by one or more radicals from the group comprising C1-C4-alkyl, C1-C4-alkoxy and halogen are valuable, intermediates for the preparation of biologically active compounds. They can be prepared by reacting a compound of the formula II, R2 - CO - NH - CH2 - OH (II) with compounds of the formula III, H - p(O)(OH)R1 (III) …