(1s) -hydroxyalkyl-oxapenem-3-carboxylic acids and their use as betalactamase inhibitors

Abstract From the Canadian patent

The invention relates to 1-oxapenem-3-carboxylic acids of the following structure:, in which R1 R3, R4 and R5 independently of one another denote pharmaceutically acceptable groups which are connected to the other part of the molecule via carboncarbon single bonds and which contain 1 to 10 carbon atoms, and in which R2 is hydrogen, alkyl or acyl having up to 10 carbon atoms or an inorganic acid residue. These compounds as well as their pharmaceutically, acceptable salts esters and amide derivatives are, especially useful betalactamase inhibitors. Subject of the invention are also pharmaceutical preparations containing these compounds and procedures for medication as well as procedures for …