Pseudomonas exotoxin multifunctional fusion proteins having carboxyl alterations with increased cytotoxicity
CA 2082824 C · Owner: Pastan, Ira · Inventors: Chaudhary, Vijay K.; Pastan, Ira; Fitzgerald, David
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional recombinant, cytotoxic, fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 10, 1991 and granted October 6, 1998. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 10, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 10, 2013.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.