4-(oxygen, sulfur or nitrogen substituted) -methyl 5-hydroxy-2 (5h) - furanones as anti-inflammatory agents

Abstract From the Canadian patent

Compounds of formula (1) in which R1 is H or alkyl of 1 to 20 , carbons CO-R1* CO-O-R1* CO-NH-R1* or PO(OR1*)2 or PO(OR1*)R1* where R1* independently is H alkyl of 1 to 20, carbons, phenyl, or substituted phenyl; X is O S, SO-, SO2, NH-, or NR2 where R2 is phenyl substituted phenyl or alkyl of 1 to, 20 carbons and Y is alkyl having at least 6 carbon atoms arylalkyl, aryl, substituted aryl, substituted arylalkyl alkenyl, containing one or more olephinic bonds and at least 6 carbon atoms CO-R3, CO-OR3, CONHR3, SO2R3, SO2NHR3 where R3 is aryl, substituted aryl, substituted arylalkyl alkyl, alkenyl, containing one or more olephinic bonds further Y is, (CH2)n-O-R4, or (CH2)n-O-(CH2)m-O-R4 where …