Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace

Abstract From the Canadian patent

The present invention relates to compounds of the formula, (see Formula I), wherein, B1 and B2 are each independently hydrogen; hydroxy; -OR2 wherein R2 is a C1-C4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C1-C4 alkyl; or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;, A is a bond, methylene or oxygen sulfur or NR4 or NCOR5, wherein R4 is hydrogen a C1-C4 alkyl or an Ar-Y- group, and R5 is -CF3 a C1-C10 alkyl or an Ar-Y- group;, R3 is hydrogen or -CH2OC(O)C(CH3)3; R1 is hydrogen, C1-C4 alkyl or -CH2OC(O)-C(CH3)3; and n is an integer 1 to 3, which are useful as …