Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists

Abstract From the Canadian patent

Compounds of the formula: where R is Het-R', where Het is substituted 5 membered heterocyclic rings containing 1 or 2 99/FPG57, -ii- 18538, heteroatoms, wherein said heteroatoms are N; R' is independently one or more of hydrogen oxo amino or, unsubstituted or substituted alkyl where said alkyl, substituent is independently one or more of hydroxyl amino, oxo, sulfonyl, alkylsulfonyl, carboxyl phenyl, indole, alkoxycarbonyl, alkoxycarbonylamino imidazole or pyrrolidine. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the, stoppage of labor preparatory to cesarean delivery timing of parturition, uterine hyperactivity …