Method and compositions for inhibiting angiogenesis

Abstract From the Canadian patent

Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a specific inhibitor of collagenase, for inhibition of blood vessel ingrowth and tube formation in vivo and capillary endothelial cell proliferation and migration in vitro, which is non-cytotoxic to normal cells. The compositions are delivered topically or locally using implants or injection. Examples of specific collagenase inhibitors include purified cartilage-derived inhibitor collagenase binding, peptides and antibodies which block the active site or metal binding regions of collagenase, and compounds which inhibit enzymes activating collagenase, such as plasmin inhibitor.