Cyclic peptides containing arg-gly-asp flanked by proline
CA 2073696 A1 · Owner: Genetech, Inc. · Inventors: Barker, Peter L.; Burnier, John P.; Lazarus, Robert A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A small cyclic peptide is provided having high affinity for the platelet GP IIbIIIa receptor, which peptide is represented by formula .alpha. where R1 and R4 are from 0 to 4 amino acids R3 is from 1 to 4 amino acids; R2 is -CH2CO- or from 1 to 4 amino acids; Xaa8 may be Met, Phe, nLeu Ile, Asp, Lys, Arg and , Gln; and Z is a linking group either disulfide, thioether or, amide, but preferably disulfide. Preferred cyclic peptides exhibiting high inhibition potency in a platelet aggregation assay are represented by formula .beta. where Xaa2 Xaa3 and Xaa4 may be , any amino acid but preferably are Arg Ile and Pro, respectively. Xaa8 is preferably Met Phe or nLeu; Xaa10 when present, is , …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed January 28, 1991. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended January 28, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by January 28, 2013.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.