Cycloalkyl-substituted glutaramide antihypertensive agents

Abstract From the Canadian patent

Compounds of formula (I) wherein A completes a 5 or 6 membered, carbocyclic ring which may be saturated or monounsaturated; Y is an alkylene group of from 1 to 9 carbon atoms; R1 is H or (C1-C4)alkyl; R and R4 are H, (C1-C6)alkyl (C3-C7)cycloalkyl, benzyl, or an alternative biolabile ester-forming group; R2 is defined to include a range of substituent groups including (C1-C6)alkoxy, (C1-C4)alkoxy-(C1-C6)alkoxy and various substituted-alkyl, amino, substituted amino aryl and, heterocyclyl substituents linked directly or by O S(O)n, NR6, CO or, CONR6 wherein R6 is H (C1-C4)alkyl or, aryl(C1-C4)alkyl and n is 0 1 or 2; R3 is a group of formula (II), wherein R13 is H, halo, 4-OH, 4-(C1-C6 …