Cycloalkyl-substituted glutaramide diuretic agents

Abstract From the Canadian patent

Compounds of formula (I) wherein A completes a 4 to 7 membered, carbocyclic ring which may be saturated or mono-unsaturated and which may optionally be fused to a further saturated or unsaturated 5 or 6 membered carbocyclic ring; R is H C1-C6 alkyl, benzyl or an alternative biolabile ester-forming group; R1 is H or C1-C4 alkyl; R2 is H, OH, C1-C4 alkyl, C1-C4 alkoxy halo or CF3; R3 is CH2OH or CO2R4 where R4 is as defined for R; and R5 is defined to include a range of alkyl alkenyl, alkynyl, cycloalkyl, cycloalkenyl and substituted alkyl, groups including in particular methoxyethyl S-lysylamino-methyl, N2-acetyl-S-lysylaminomethyl and N2-methanesulphonyl-S-lysyl-aminomethyl are …