Enantioselective synthesis of l-(-)-4-boronophenylalanine (l-bpa)
CA 2070202 A1 · Owner: Samsel, Edward Gerrard · Inventors: Samsel, Edward Gerrard
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method of making substantially pure L-BPA is disclosed. The method includes the steps of reacting 4bromobenzaldahyde with ethylene glycol to form 4bromobenzaldehyds ethylene glycol acetal sequentially, reacting 4-bromobenzaldehyde ethyleneglycol acetal with Mg to produce the Grignard reagent and thereafter reacting with tributyl borate and then converting to an acid environment to form 4-boronobenzaldehyde, reacting 4-boronobenzaldehyde with diethanol amine to form 4-boronobenzaldehyde diethanolamine ester, condensing the 4-boronobenzaldehyde diethanolamine ester with 2-phenyl-2-oxazolin-5-one to form an azlactone, reacting the azlactone with an alkali metal hydroxide to form …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 2, 1992. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 2, 2012.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 2, 2014.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.