Process for making peptides containing aza-amino acids

Abstract From the Canadian patent

A process for the solid phase synthesis of peptides containing a C-terminal aza-amino acid, for example the decapeptide goserelin which comprises:, (i) reacting an active ester or imidazolide of an N-protected aza-amino acid either with an appropriate reactive solid support in the case of the synthesis of a peptide containing a C-terminal aza-amino acid, or with a peptide which is attached to a solid support in the case of the synthesis of a peptide containing a non-C-terminal aza-amino acid;, (ii) carrying out further conventional solid phase peptide synthesis steps to add sequentially further amino acids to form a peptide, with the required amino acid sequence bound to the solid support; …