Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants

Abstract From the Canadian patent

Disclosed are paucilamellar lipid vesicles made of single chain nonphospholipid anionic or zwitterionic surfactants and a method of their manufacture. The preferred vesicle-forming materials are single chain sarcosinamides having 12-20 carbon chains and single chain betaines, the use of which obviates problems associated with using phospholipids as artificial membranes such as degradation by a large variety of enzymes autocatalyzed, peroxidation and high cost. The vesicles are formed rapidly and can be used to encapsulate aqueous or oily solutions. The vesicles may be used for transporting a whole spectrum of molecules, including macromolecules and drugs vaccines, other therapeutic …