Direct radiolabeling of antibodies and other proteins with technetium or rhenium
CA 2065299 C · Owner: Rhodes, Buck A. · Inventors: Rhodes, Buck A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of he protein using Sn (II), or using other seducing agents followed by the addition of Sn (II), removal of excess reducing agent and reduction by-products; and addition of a specified amount of pertechnetate or perrhenate reducing agent such as stan-, nous tartrate; with the addition accomplished in such a manner that further reduction of the protein is limited. The,resulting product may be stored frozen or lyophilized with …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed August 8, 1990 and granted July 24, 2001. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended August 8, 2010.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by August 8, 2012.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.