Macrolides for the treatment of reversible obstructive air-ways diseases

Abstract From the Canadian patent

Compounds of formula (I), wherein R1 and R2 together represent two vicinal hydrogen atoms, or form a second bond, between the vicinal carbon atoms to which they are attached; R3 represents H OH, alkoxy or protected hydroxy; R4 represents OH; R5 represents H, alkyl or alkenyl; R6 and R7 independently represent O, (H,OH), (H,protected hydroxy) or (H,alkoxy); X and Y independently represent O (H,OH) or (H,H); n is 1 or 2; or , pharmaceutically acceptable derivatives thereof; are provided for the treatment of reversible obstructive airways disease particularly asthma. Compositions containing such compounds are also disclosed.