Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
CA 2050336 C · Owner: Norris, Kjeld · Inventors: Norris, Kjeld; Bjorn, Soren; Norris, Fanny
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A polypeptide for production in yeast comprises a fusion of a signal peptide a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amine acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein or both. The heterologous protein may, for instance be …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 1, 1990 and granted January 18, 2000. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended March 1, 2010.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 1, 2012.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.