Controlled initial target-dependent production of templates for ligase chain reaction
CA 2049879 A1 · Owner: Carrino, John J. · Inventors: Carrino, John J.; Backman, Keith C.; Shimer, George H.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
An improvement to the ligase chain reaction (LCR) method of selectively and geometrically ligating nucleic acid probes; before the LCR, a template-dependent controlled reaction increases the population of templates capable of supporting template-dependent ligation in LCR selectively in the presence of target nucleic acid, while substantially avoiding creation of any molecules capable of supporting template-dependent ligation in the absence of target nucleic acid. One way to control the initial reaction is to weight the reaction to create templates corresponding to only one of the two target strands, using e.g. template dependent ligation or polymerization. Another way to control the initial …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed August 26, 1991. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended August 26, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by August 26, 2013.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.