Water soluble derivatives of taxol
CA 2049160 C · Owner: Zhao, Zhi-Yang · Inventors: Zhao, Zhi-Yang; Kingston, David G. I.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Sulfonated 2'-acryloyltaxol and sulfonated 2'-O-acyl acid taxol derivatives are synthesized which have improved water solubility and stability while maintaining bioactivity. In particular, 2'-(3-sulfo-1-oxopropyl)oxy taxol sodium salt is synthesized by reacting taxol with acrylic acid, and subsequently reacting the 2'-acryloyltaxol with bisulfite in a Michael reaction. 2'-(4-((2sulfoethyl)amino)-1,4-dioxobutyloxy)taxol sodium salt and 2'-{4-((3-sulfopropyl)amino)-1,4-dioxobutyloxy) taxol sodium salt are synthesized by reacting 2'-succinyltaxol with the tetrabutylammonium salts of taurine and 3-aminopropyl sulfonic acid, respectively, and subsequently exchanging the ammonium with sodium. …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed August 14, 1991 and granted November 18, 1997. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended August 14, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by August 14, 2013.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.