9-purinyl phosphonic acid derivatives

Abstract From the Canadian patent

This invention relates to novel purine nucleoside phosphorylase inhibitors of the formula: (see formula I), the tautomeric forms thereof and the pharmaceutically, acceptable salts thereof wherein, (see formula II), with Ar being a bridging moiety to which its adjacent CH2 moiety is bonded to one ring carbon atom and the Z moiety is bonded to a second ring carbon atom of an R9-substituted phenyl, thiophene or furan moiety, Z is a moiety of subtypes (a), (b), (c), (d), or (e) wherein (see formulas a, b, c, d, e) , to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma antileu-, kemic, antiviral and antiprotozoal agents.