Polypeptides having a .beta.-adremergic receptor activity in humans, involved_in the lipolytic response, nucleic acids coding for these polypeptides and use of these polypeptides for the screening of active substances on these polypeptides

Abstract From the Canadian patent

Novel polypeptides having a beta -adrenergic receptor activity containing the sequence of 402 amino acids or a fragment of this sequence, said fragment being such that in particular, either it nonetheless includes the sites contained in said sequence and whose presence is necessary so that when the fragment is exposed to the surface of a cell it is capable of participating in the activation of the cyclase adenylate in the presence of an agonist or it is likely to be recognized by antibodies which also recognize the above succession of 402 amino acids but fail to recognize the beta 1 adrenergic receptor and the beta 2 adrenergic receptor. These polypeptides are useful for screening drugs …