Method for producing ibuprofen
CA 2043108 C · Owner: Hoechst Celanese Corporation · Inventors: Mott, Graham N.; Hendricks, Joel D.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method is provided for the preparation of ibuprofen by carbonylating 1-(4'-isobutylphenyl)ethanol (IBPE) with carbon monoxide comprising initially a reaction mixture comprising IBPE ibuprofen and a catalyst for the carbonylation with carbon monoxide under conditions to initiate the reaction and, continuing to feed carbon monoxide to the composition to produce the desired yield of ibuprofen. Preferably the catalyst comprises palladium and a monodentate phosphine ligand. The presence of ibuprofen in the feed composition when the reaction is initiated with CO makes it possible to obtain high selectivities to ibuprofen with substantially complete conversion of IBPE at much shorter reaction …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 23, 1991 and granted July 17, 2001. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 23, 2011.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 23, 2013.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.