Ingestible amine functionalized and cross-linked homopolymers with hydrophobic backbone for the lowering of blood cholesterol

Abstract From the Canadian patent

The invention is concerned with novel ingestible cross-linked homopolymers having functional groups consisting of linear or branched amines, of the formula: P-NR(CH2)n mN(R)2 or , (Ia) (Ib), and their pharmaceutically acceptable salts of the formulae: P-N+(R)2(CH)nMN+(R)3(m+l)X- (Ic), and, (Id) wherein P represents a hydrophobic, cross-linked and nondigestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 6 inclusive; and n o and p are, independently, integers varying from 2 to 12 inclusive. The amine functionalized and cross-linked homopolymers of the invention are highly efficient …