Cyclic renin inhibitors containing 2-substituted(3s, 4s)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3s, 4s)-5-cyclohexyl-3,4-dihydroxy-pentanoic acid or 2 -substituted (4s, 5s)-5-amino-6- yclohexyl-4-hydroxyhexanoic acid or its analogs

Abstract From the Canadian patent

3/MRD2, 12/MRD11, 13/MRD12, 14/MRD13 17784IB TITLE OF THE INVENTION, CYCLIC RENIN INHIBITORS CONTAINING 2-SUBSTITUTED (3S,4S)-4-AMINO-5-CYCLOHEXYL-3-HYDROXY PENTANOIC ACID, 2-SUBSTITUTED (3S,4S)-5-CYCLOHEXYL-3,4-DI HYDROXYPENTANOIC ACID OR 2-SUBSTITUTED (4S,5S)-5- AMINO-6-CYCLOHEXYL-4-HYDROXYHEXANOIC ACID OR ITS ANALOGS, ABSTRACT OF THE DISCLOSURE, Compounds of the formula: (I), 3/MRD2, 12/MRD11, 13/MRD12, 14/MRD13 -i- l7784IB, are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension hyperaldo-, steronism, congestive heart failure and glaucoma.