Substituted cyclohexenes as central nervous system agents

Abstract From the Canadian patent

Substituted cyclohexenes are described as well as, methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic antipsychotic, and, antihypertensive agents as well as for treating hyperproloactinaemia-related conditions and central nervous system disorders. The general structure of compounds according to the invention are as shown in Formula I below. wherein R1 is aryl 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl lower, alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or …