Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them

Abstract From the Canadian patent

Compounds of formula, (see formula I), in which R1 represents H an alkyl or a substituted alkyl, R2 represents H or alkyl and R3 represents an optionally substituted cycloalkyl or an optionally substituted aromatic group, which can be a phenyl or a heterocyclic group comprising one or more hetero-atoms chosen from O S and N, or R2 and R3 considered together represent the group, (see formula II), which is optionally substituted on the phenyl ring and, Z represents a heterocycle comprising one or more heteroatoms chosen from O, S and N, fused with an aromatic ring which can comprise a hetero-atom and can be substituted the said heterocycle being optionally substituted on N when it comprises …