5-1-(imidazol)methyl-3,3-disubstituted-2(3h)furanone derivatives

Abstract From the Canadian patent

Furanone compounds and compositions having anticholinergic activity are described. The compounds have the formula:, wherein:, the dashed line indicates either the 4,5-unsaturated or the 4,5-dihydrofuranone ring;, R1 and R2 may be the same or different and are hydrogen, thienyl, furanyl, or cycloalkyl (C3-C6) benzyl, phenyl, substituted phenyl or substituted benzyl wherein the phenyl or benzyl group may be substituted with halogen trifluoromethyl, lower alkyl, lower alkoxy or hydroxy; R3, R4 and R5 may be the same or different and are hydrogen, lower alkyl, lower alkyl substituted with a halogen, alkoxy, amino or carboxylic acid group an alkyl or, alkylene bridge between R4 and R5 or R3 and …