Enzymatic process for the production of n-acetyl neuraminic acid
CA 2029984 C · Owner: Ciba-Geigy Ag · Inventors: Ghisalba, Oreste; Kragl, Udo; Wandrey, Christian
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A process for obtaining N-acetylneuraminic acid from N-acetylglucosamine is disclosed The, process is carried out in a reactor which contains both N-acylglucosamine-2-epimerase (E.C. 5,1.3.8) which isomerizes GlcNAc into ManNAc, and N-acetyl-neuraminic acid pyruvate lyase (E.C. 4.1.3.3) which catalyzes the reaction of the resulting ManNAc with pyruvic acid to give Neu5Ac, GlcNAc and Pyr are fed into the reactor and Neu5Ac is obtained in the outglow. The process is preferably carried cut continuously and in particular in an enzyme membrane reactor at pH 7.5 and 25°C, especially using residence times of 0. 2 to 10 h, and with an excess of GlcNAc in comparison with Pyr which is subsequently …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 14, 1990 and granted May 2, 2000. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended November 14, 2010.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 14, 2012.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.