5-{2-(2-amino-2-oxoethyl) (methyl)aminoethyl}-2,3-dihydro-3-hydroxy-2-(4-methoxyphen yl)-1,5(5h)-benzothiazepin-4-one derivatives, their preparation and their application in therapy

Abstract From the Canadian patent

A compound, in the form of a pure diastereoisomer or a mixture thereof, of formula (I), (I) in which, R1 represents a hydrogen atom or a C2-C4 alkanoyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, n represents an integer of from 0 to 3 and, R3 represents either a phenyl group bearing from 1 to 3 substituents selected from halogen atoms and trifluoromethyl, methyl, C1-C4 alkoxy or alkylthio nitro, cyano, carbamoyl, acetamido, methanesulphonamido methoxycarbonyl or phenylcarbonyl groups or an aromatic, heterocyclic group;, or a pharmacologically acceptable acid addition salt thereof.