Process for the chemical resolution of 5-alkoxy-substituted (+)-1,3-dimethyloxindolyethylamines

Abstract From the Canadian patent

Abstract, Process for the chemical resolution of 5-alkoxy-substituted (?)-1,3-dimethyloxindolylethylamines, A process for chemically resolving a mixture of enantiomers of primary amines, such as enantiomers of 1,3-dimethyl-5-methoxyoxindolylethylamine provides one of, the enantiomers in the form of a tartaric acid salt. In carrying out the process, an enantiomeric mixture is contacted with a chiral acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The resulting precipitate can then be recovered. The chiral acid is selected from the group consisting of dibenzoyl-D-tartaric acid dibenzoyl-L-tartaric, acid, ditoluoyl-D-tartaric …